Vivregen LLC

Technology

Soft tissue damages are commonly caused by trauma, disease or surgery. Improper or inadequate healing results in chronic inflammation and pain, degenerative conditions such as arthritis and ultimately lameness. Regenerative technologies can be complementary and sometime superior alternatives to traditional pharmaceuticals for animals that suffer from acute and chronic inflammation, diminished agility and reduced performance due to aging, injuries or overuse.

VIVR8 is a non-cellular biological matrix containing mediators secreted by stem cells during an active regeneration process. The matrix contains a broad range of growth factors, immunomodulators and matrix proteins and polymers known to promote tissue regeneration while reduce scarring and pain associated with inflammation. At the injured area, VIVR8 acts as a scaffold to recruit cells involved in regulating inflammation and regeneration (such as stem cells and progenitor cells) to deposit into the matrix. 

Whether it’s a tendon or ligament tear, or a muscle strain, or arthritis marked by chronic inflammation and pain, VIVR8 enhances healing by rapidly reducing inflammation, triggering abundant new blood vessel formation while recruiting numerous stem cells or progenitor cells to the injury site. These cells have the potential to differentiate, organize and develop into the numerous types of site specific tissues needed to repair the injured organ without the formation of scar tissue.

UPDATE:

Stem Cells: When will they heal the heart?
It’s been 15 years since a University of Wisconsin-Madison researcher isolated embryonic stem cells — the do-anything cells that appear in early development. …And yet the early hope to grow “spare parts” — turning stem cells into specialized cells for repairing a failing brain, pancreas or heart, remains mostly promise rather than reality.”

This fascinating article provides both perspective and insight into the extraordinary promise as well as reality of using stem cells to heal organ damage.  Rather than cell replacement, scientists believe that stem cells secrete “good vibes” that either attract innate stem cells from the host or help preserve heart muscle cells that are damaged, a belief that echoes the principle behind VIVR8. To read the full article, click on the link here: http://whyfiles.org/2013/stem-cell-therapy-when-will-it-help-the-heart/

Comparison of Stem Cells and Their Conditioned Media in Healing of Diabetic Wounds
An important breakthrough in the stem cell research is the discovery that transplanted stem cells do not survive in the new environment and the benefits of stem cell therapy are largely derived from the proteins secreted by the stem cells. The natural question is then can we use the stem cell proteins as a healing agent rather than the stem cells themselves? This question has led us to the development of VIVR8.

The concept behind VIVR8 technology is supported by a recent publication comparing mesenchymal stem cells (MSC) and their conditioned media (CM, containing proteins secreted by stem cells but not stem cells themselves) in diabetic wound animal model. Both the transplantation of MSC and their CM are beneficial to diabetic wound healing, but CM has been shown to be therapeutically better than MSC, at least in the context of diabetic wound healing. To read the full article, click here: http://www.hindawi.com/journals/ije/2013/592454/

If you are interested in learning more about our technology, please contact us at 1-888-552-0277, email us at info@vivregen.com or ask your veterinarian to get in touch with us.